Transdermal drug delivery system of Metformin Hydrogen Chloride using Two Different Polymeric Combinations

Abstract

This present study was to develop a suitable matrix-type transdermal drug delivery system (TDDS) of metformin hydrogen chloride (HCL) using two different polymeric combinations, i.e., hydroxyl propyl methyl cellulose and ethyl cellulose (EC). Six matrix patches were prepared by using these polymers using propylene Glycol as plasticizer and vegetable oils (eucalyptus oil) as permeation enhancers in dichloromethane and Methanol(1:1) as a solvent system. The formulations were characterized, including uniformity of weight, drug content, moisture content, moisture uptake, flatness, folding endurance, and thickness to study. The stability of the formulations and in vitro dissolution of the experimental formulations were performed to determine the amount of metformin HCL present in the patches, and scanning electron microscopy (SEM) of the prepared TDDS were taken to see the drug distribution pattern. Drug–excipient interaction studies were carried out using Fourier transform infrared (FTIR) spectroscopic technique. In vitro dissolution studies showed that the drug distribution in the matrix was homogeneous and it was found that the maximum drug release in 24 hrs was with formulation F6 (containing Eucalyptus oil