ESTIMATION OF SERUM COPPER AND ZINC LEVEL IN PATIENTS WITH ORAL SUB MUCOUS FIBROSIS AND ORAL SQUAMOUS CELL CARCINOMA

Abstract

Trace elements are receiving too much attention as they are found to be significantly altered in head and neck, lung and breast carcinomas, and there is need to develop sensitive, specific and faster tests as an aid in the early diagnosis of the primary tumor and its recurrence or malignant transformation in premalignant states.Aim: To estimate serum copper and zinc levels in Oral Submucous Fibrosisand oral squamous cell carcinoma patients. Methodology: Sera of OSCC (n = 10) and OSMF (n = 10) patients and of healthy controls was analysed for the estimation of Cu and Zn using atomic absorption spectrophotometry. Results: There was an increase in sera levels of Cu while those of Zn were decreased in both Oral Submucous fibrosis and Oral Squamous Cell Carcinoma patients as compared to the healthy controls. Conclusion: It could be concluded that there is an alteration of sera levels of these trace elements which can be helpful in early detection and management in OSMF and OSCC patients.